Liquid biopsy has become a useful tool for targeted cancer treatment selection. It also has immense potential as a monitoring tool for the emergence of treatment resistance. 

To advance this potential, Canexia Health is collaborating with Exactis Innovation on a clinical study to monitor plasma circulating tumor DNA (ctDNA) in metastatic colorectal cancer patients using Canexia’s Follow It® assay to detect changes in mutations and disease progression. Exactis Innovation is a Canadian National Centre of Excellence in Personalized Medicine comprising a network of 16 oncology centers bringing together public and private partners focusing on precision oncology.

Study objectives included:

  • Using a retrospective collection of 55 metastatic colorectal cancer patients enrolled on a clinical trial to determine if longitudinal plasma ctDNA mutation monitoring can aid in predicting clinical progression prior to standard of care CT imaging
  • Identifying resistance mechanisms in patients undergoing therapy
  • Establishing Canexia’s Follow It assay as a liquid biopsy tool to assess disease progression over time in metastatic colorectal cancer patients

Among the findings:

  • PIK3CA mutations are significantly enriched in treatment resistance patients and thus may be a resistance mechanism in this mCRC cohort
  • KRAS and PIK3CA are enriched as co-mutated in the resistance population
  • RAS wildtype patients often harborTP53 mutations that can be used for ctDNA monitoring
  • In the metastatic setting, Follow It detects CRC driver ctDNA mutations in serial longitudinal patient plasma samples within a clinical trial


Recent Resources


February 3, 2023

Cutting-edge precision oncology, where the patient is

The theme for this year’s World Cancer Day is Close the Care Gap. Health equity is a pillar of our work at Imagia Canexia Health. So today our Chief Medical Officer, Dr. David Huntsman, is opening the conversation to showcase how our community-centered approach to cancer care is improving access to genomic-driven cancer care for all.


December 1, 2022

Holiday Lab Hours

The holiday season is around the corner and we would like to inform everyone of our operation schedule over Christmas and New Year.